A collection of essays presented at "Frater, Magister, Minister, Episcopus. The Works and Worlds of Bonaventure," a conference held at St. Bonaventure University, commemorating the 800th Centennial of Saint Bonaventure, the Seraphic Doctor.

Explores the relationships among hypertext, rhetoric, and philosophy.

Naloxone, which reverses the effects of opioids, was synthesized in 1960, though the hunt for opioid antagonists began a half-century earlier. The history of this quest reveals how cultural and medical attitudes toward opioids have been marked by a polarization of discourse that belies a keen ambivalence. From 1915 to 1960, researchers were stymied in seeking a “pure” antidote to opioids, discovering instead numerous opioid molecules of mixed or paradoxical properties. At the same time, the quest for a dominant explanatory (...) and therapeutic model for addiction was likewise unsettled. After naloxone’s discovery, new dichotomizing language arose in the “War on Drugs,” in increasingly divergent views between addiction medicine and palliative care, and in public debates about layperson naloxone access. Naloxone, one of the emblematic drugs of our time, highlights the ambivalence latent in public and biomedical discussions of opioids as agents of risk and relief. (shrink)

Everyone has a different "learning style". (A good introduction to the topic of learning styles is Claxton & Murrell 1987. For more on different learning styles, see Keirsey Temperament and Character Web Site, William Perry's Scheme of Intellectual and Ethical Development, Holland 1966, Kolb 1984, Sternberg 1999. For an interesting discussion of some limitations of learning styles from the perspective of teaching styles, see Glenn 2009/2010.) For some online tools targeted at different learning styles, see "100 Helpful Web Tools (...) for Every Kind of Learner". (shrink)

This article attempts a contextual study of the origin and early development of August Kekulé's theory of aromatic compounds. The terminus a quo is essentially August Hofmann's coining of the modern chemical denotation of ‘aromatic’ in 1855; the terminus ad quem is the first full codification of Kekulé's theory in the sixth fascicle of his Lehrbuch der organischen Chemie, published in the summer of 1866. Kekulé's theory is viewed in context with the earlier and concurrent experimental work of such chemists (...) as Hermann Kolbe, Friedrich Beilstein, Rudolph Fittig, and Hugo Müller. The reception of the theory is briefly examined. Attention is paid to the role of Kekulé's molecular models and of his celebrated dream anecdote of the snake that seizes its own tail. The episode is used as a case study for the continuity of scientific progress, and to illustrate the close reciprocal interactions of hypothesis and experiment in the evolution of a scientific theory. (shrink)

Kolb's purpose is to dispel a practical and theoretical illusion--promoted by modernity about its own uniqueness as a unified and unifying constellation of meanings which wholly defines us--and to put modernity "in its place" within that sustaining and limiting context which makes it possible, which cannot be described in "standard modern terms," and which suggests that we are not as free as--and yet more than what--modernity says we are. He begins with an examination of the "standard self-description of modernity (...) and its basic dichotomies and divisions," in particular the modern preference for formal over substantive rationality, emphasized by Max Weber in his presentation of modern society as "a process waiting for content to come from the choice of its citizens"--the modern self relating "to itself and to others as a pure chooser, with no necessary substantive content". (shrink)

The early modern period (roughly, 1600–1800 ce) in Europe brought tremendous changes in intellectual, political, and cultural life. It was a period in which philosophical debates were inevitably bound up with questions about the nature and sources of religious truth. A chronological examination of some of the period’s major thinkers highlights two issues that were central to the development of philosophy of religion in the period. The first concerns the relations between God, the soul, and the body; the other concerns (...) the relationship between human reason and divine revelation. (shrink)

A critique of Strawson's distinction between descriptive and revisionary metaphysics.

Cet ouvrage ne présente pas un système complet et cohérent, méritant le nom d'une philosophie du droit international. Une telle entreprise serait à la fois trop vaste face à une société internationale de haute complexité et aussi un peu anachronique au regard de la perte de foi dans les systèmes trop parfaits et dès lors trop réductifs. C'est plutôt une série de réflexions personnelles sur les points de droit international qui m'ont paru importants au fil des années d'étude de cette (...) matière, que je veux ici présenter. Si ces points ne s'ordonnent pas en un système, ils ne sont néanmoins pas jetés sur le papier au hasard. Ces réflexions ont ceci en commun qu'elles tentent de serrer de plus près les aspects ordonnateurs et structurants du droit international, en un mot, ses chevilles ouvrières aux points charnière ou ses voûtes névralgiques. Ces réflexions s'ordonnent autour de trois axes. Dans une première partie, il s'agit de dégager quelques caractéristiques fondamentales du droit international, qui expliquent et imprègnent ses applications. Après une discussion des types possibles de droit international et de leur réalisation dans l'histoire, il est question des grandes phases d'évolution qu'a connues le droit international depuis le temps de Grotius. Ensuite, les caractéristiques propres des sources du droit international (les sources constituant une espèce de radiographie de tout ordre juridique) sont examinées. Parmi les autres caractéristiques de la règle internationale, ce sont notamment sa tendance à l'individualisation, à l'ouverture vers les circonstances particulières des espèces, ainsi que les incidences de cette tendance, qui font l'objet de considérations. Enfin, il est question de la règle " tout ce qui n'est pas interdit est permis ", renforcée en droit international par la souveraineté. De sa place et de ses rôles exacts dépend la nature et la force de l'ordre juridique en question. Dans une seconde partie, ce sont les relations multiples du droit et de la politique qui font l'objet d'analyses. Si la politique est un facteur essentiel de vie et de réalisation de tout droit (et aussi une menace pour lui), il en est à plus forte raison ainsi en droit international, où les deux branches, droit et politique, sont particulièrement proches. L'analyse ne se borne pas à des relations stéréotypées, mais tente de dégager en catégories d'espèces une multitude de pesées réciproques entre les deux branches, dans leurs vertus centripètes et centrifuges. Enfin, dans une troisième partie importante, c'est une série de notions juridiques cardinales qui forme l'objet des réflexions. Il s'agit du bien commun ; de la justice ; de la sécurité juridique ; de la réciprocité, de l'égalité et de la proportionnalité ; de la liberté ; de la morale et de la morale sociale ; de la volonté dans ses rapports avec la raison ; de la sanction. Il s'agit de voir quelle est la configuration que l'expérience juridique générale a donnée à ces notions et par la suite d'examiner comment elles peuvent s'insérer et agir au sein du droit international au regard des spécificités de la société internationale, avec quelles analogies mais aussi avec quelles altérations ou adaptations. C'est ainsi qu'on peut dégager ce degré d'orientation juridique inhérent au " droit international " dans ses forces et ses faiblesses. (shrink)

Recent studies indicate that mammalian chromosomes contain discretecis‐acting loci that control replication timing, mitotic condensation, and stability of entire chromosomes. Disruption of the large non‐coding RNA gene ASAR6 results in late replication, an under‐condensed appearance during mitosis, and structural instability of human chromosome 6. Similarly, disruption of the mouse Xist gene in adult somatic cells results in a late replication and instability phenotype on the X chromosome. ASAR6 shares many characteristics with Xist, including random mono‐allelic expression and asynchronous replication timing. (...) Additional “chromosome engineering” studies indicate that certain chromosome rearrangements affecting many different chromosomes display this abnormal replication and instability phenotype. These observations suggest that all mammalian chromosomes contain “inactivation/stability centers” that control proper replication, condensation, and stability of individual chromosomes. Therefore, mammalian chromosomes contain four types ofcis‐acting elements, origins, telomeres, centromeres, and “inactivation/stability centers”, all functioning to ensure proper replication, condensation, segregation, and stability of individual chromosomes. (shrink)

The workshop – presented by the director of a new center and the coordinator of an alliance intended to amplify and extend the influence of an established center – focused on the challenges involved in founding, growing, and sustaining centers for business ethics within university business schools. The discussion draws on experience at the Center for Business and Society, Leeds School of Business, University of Colorado, and the Center for Business Ethics, Bentley College and Bentley’s Alliance for Ethics & Social (...) Responsibility. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:A Defense of Poetry: Reflections on the Occasion of WritingJack KolbA Defense of Poetry: Reflections on the Occasion of Writing, by Paul H. Fry; 256 pp. Stanford: Stanford University Press, 1995, $45.00 cloth, $16.95 paper.And the worm turns. It might elicit dubious laughter from those Yale critics who taught Paul Fry, now William Lampson Professor at their institution, by his admission a Berkeley student in the 1960s (and (...) still, clearly, trying to come to terms with the absolutism of his era), to have him (a)rise to the occasion of verse. After all, the question he asks at the outset of his study—“how are we to account for all the poetry, not to mention fiction, not to mention all the criticism... that still gets written?”—seems anathema except to us academic conservatives, those who resent the encroachment of sterile philosophic approaches into literature. And irrelevant to those writers who don’t give a damn about academic criticism. Fry’s reality, and not just his literary reality, here confronts the weight of academia.What is most troublesome to me about this worthy book is the vast prolegomena that seems, alas, de rigueur these days, the critical dross that Fry must apparently spend an inordinate amount of time attempting to placate, dodge, and negotiate. If academic criticism must perform such elaborate obeisance to questionable philosophies of literature, then academic criticism is truly dead. No reason to grieve: it will be replaced by those who seek to understand and relish literature, still informed by the worthy questions of imitation and audience and authorial psychology, and even internal construction that have enticed readers for centuries.Fry is anything but a happy deconstructionist. One senses immediately that he is distinctly discontented with theoretical discourse, that what he really wants to discuss is poetry, and the poetic impulse. And when he does, he does it brilliantly. Indeed, it is only his argument that inhibits him. To oversimplify (an inevitable process in this book), Fry wants to rescue some poetry from the self-destructiveness, as he sees it, of sterile critical approaches—mostly from the neo-historicists, but also from all others who would deny the essential job of poetry to replicate reality. Both human and historical values have got in the way [End Page 522] of this “pure” conveyance. Somehow poetry (unique of the arts) can escape this:It is the function of indication, of saying that something just is (to which until now I have confined my notion of ostension), to estrange utterance from its historical situation by refusing to say that that something is predicated upon, determined by, something else, whether in narrative, description, or explanation....This is the moment, completing the structure of ostension, which reduces the estranged, necessarily “situated” utterance to sound and trace, and thus returns it to the unsignifying sphere of actuality, of things in themselves, from which history for its part is by nature forever estranged. Literature, then, is that mode of utterance which lays bare the irreducible distance between history and actuality from the parti pris of the latter. By suspending our purposeful engagement with the world, it reattaches itself to the world.(pp. 54–55)No single passage can do Fry justice, for his approach is accretive, and fearsomely intelligent (this is one of the few books of contemporary criticism I’ve read in which I felt that the awful vocabulary was merited). Yet, ultimately, Fry’s ontology sounds very much like old-fashioned mimesis; it is the universality of experience, he asserts, that escapes the historicist or the dogmatist or the deconstructionist. At some level poetry is what it is. In fact what Fry seemingly wants is in his terms an obliteration of the mediation of mimesis: his true poetry wants to be reality, or at least as close as we come to it in art.Of course the problem with this definition of poetry is that it is, despite Fry’s twistings and turnings, a definition of poetry. Poetry, as even Plato tells us, is an imitation. So how do we try to get closest to reality? With poetry, Fry suggests; poetry that acknowledges the universal reality... (shrink)

While various definitions of moral distress have been proposed, some agreement exists that it results from illegitimate constraints in clinical practice affecting healthcare professionals’ moral agency. If we are to reduce moral distress, instruments measuring it should provide relevant information about such illegitimate constraints. Unfortunately, existing instruments fail to do so. We discuss here several shortcomings of major instruments in use: their inability to determine whether reports of moral distress involve an accurate assessment of the requisite clinical and logistical facts (...) in play, whether the distress in question is aptly characterized as moral, and whether the moral distress reported is an appropriate target of elimination. Such failures seriously limit the ability of empirical work on moral distress to foster appropriate change. (shrink)

In 1993, after an optimistic beginning followed by a half-decadeof conflict, the Superconducting Super Collider (SSC) project wasabandoned. In an era of `Big Science', a major scientificenterprise collapsed. Why? We employ the metaphor of the`frontier outpost' to analyse a critical moment in the history ofthis vastly expensive project, when the physicists who designedthe machine were forced to recognize that traditional post-warscientific values were no longer in harmony with governmentpriorities.

Introduction to a volume on Hegel, asking why his thought continues to be relevant today.

Vaesen infers unique properties of mind from the appearance of specific cultural innovation – a correlation without causal direction. Shifts in habitat, population density, and group dynamics are the only independently verifiable incentives for changes in cultural practices. The transition from Acheulean to Late Stone Age technologies requires that we consider how population and social dynamics affect cultural innovation and mental function.